loline Property

Boiling point:

103 °C(Press: 5 Torr)

Density 

1.20±0.1 g/cm3(Predicted)

pka

9.36±0.20(Predicted)

Hazard and Precautionary Statements (GHS)

loline Chemical Properties,Usage,Production

Description

This oily alkaloid has been obtained from a species of grass, Lotium cuneatum Nevski. It has a density of D ²⁰ 1.1343 and a refractive index of n²⁰_D 1.5505. It behaves as a diacidic base yielding a series of well crystalline salts and derivatives, e.g. the dihydrochloride, m.p. 256-7°C; [α]¹⁵_D + 6.2° (H20); dihydrobromide, m.p. 254-5°C (dec.); [α]²⁰_D + 3.5° (c 4.29, H20); dihydriodide, m.p. 233-5°C (dec.); [α]³⁴_D + 5.0° (c 13.2 H20); perchlorate, m.p. 282°C with almost explosive decomposition; sulphate, yellow needles, m.p. 250-2°C (dec.); mononitrate,m.p. 208-2l0°C; dinitrate, m.p. l48-9°C; [α]³⁸_D + 6.18° (c 6.94, H20); dipicrate, m.p. 258-260°C (dec.); methiodide, m.p. 2l0-loC and the N-nitroso derivative, m.p. 64°C. The N-acetyl derivative yields a crystalline hydrochloride, m.p. 197-8°C; [α]²⁰_D + 36.9° (H20) and the N-methyl compound is obtained as a colourless oil, b.p. 90-l oC/2 mm; [α]³¹_D+ 9.31° (c 9.5, MeOH). The alkaloid possesses an ether oxygen bridging the pyrrolizidine moiety.

Definition

ChEBI: Loline is a loline alkaloid with formula C8H14N2O. It is a secondary amino compound and a loline alkaloid.

Hazard

A poison.

References

Yunusov, Akramov., J. Gen. Chern., USSR, 25, 1765 (1955)
Yunusov, Akramov., ibid, 30,699,705,3105 (1960)